Functional Anatomy of the Endocrine Pancreas
Normal wound healing is a dynamic and multistep process involving coordinated interactions between diverse immunological and biological systems that result in the restoration of anatomical continuity and function . Before we dive into the phases of wound healing, let us familiarize with basic components involved in this process. Platelets and inflammatory cells are the first cells to arrive at the site of injury and they provide "signals" needed for the influx of connective tissue cells and the generation of a new blood supply. These chemical signals are known as cytokines or growth factors. The fibroblast is the connective tissue cell responsible for collagen deposition that is needed to repair the tissue injury. Collagen is the most abundant protein in the animal kingdom, accounting for 30% of the total protein in the human body. In normal tissues, collagen provides strength, integrity, and structure. When tissues are disrupted following injury, collagen is needed to repair the defect and restore anatomic structure and function .
What is the Endocrine System? | US EPA
The patients who underwent this treatment showed unprecedented improvement in viable heart mass and contractility in just six months. The study gained wide appreciation for its success. The CADUCEUS Study deemed autologous transfer of stem cells for the treatment of ventricular dysfunction a safe procedure warranting extension of the study into phase II . The pharmacological and surgical approaches leave behind scars of damaged cardiac tissue. The promise of stem cell therapy for treating ischemic heart diseases is now a feasible therapeutic option. The POSEIDON, SCIPIO, SWISS-AMI, CADUCEUS, and CCTRN trials as well as the TIME, LateTIME, and FOCUS clinical trials have been instrumental in demonstrating the efficacy and safety of mesenchymal, cardiac, and bone marrow–derived mononuclear cells in reducing infarct size and improving heart muscle contractility. Preclinical studies have now indicated that a cocktail of cardiac and mesenchymal stem cells could be more effective in restoring cardiac function. Thus, studies exploring more efficient delivery systems, the optimal combination of stem cells, and the mechanism orchestrating the beneficial effects observed, are being pursued [13-19].
First, as they grow large tumors of the pancreas will interfere with both of these important bodily functions. When tumors block the exocrine system, patients can develop pancreatitis and pain from the abnormal release of digestive enzymes into the substance of the pancreas instead of into the bowel, and they can develop digestive problems, such as diarrhea, from the incomplete digestion of food. When tumors destroy the endocrine function of the pancreas, patients can develop sugar diabetes (abnormally high blood sugar levels).
Endocrine System: Discover the Anatomy and - InnerBody
The second functional component of the pancreas is the "endocrine" pancreas. The endocrine pancreas is composed of small islands of cells, called the islets of Langerhans. These endocrine cells don’t release their secretions into the pancreatic ducts, instead they release hormones, such as insulin and glucagon, into the blood stream, and these hormones in turn help control blood sugar (glucose) levels.