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In addition, the Task Group concluded that, in view of the dependence of selenium deficiency or toxicity effects on various environmental factors, the possible involvement of selenium in human diseases of multifactorial etiopathogenesis deserves special attention.

Selenium (EHC 58, 1986) - INCHEM

Furthermore, the authors recognized that there was need to investigate further the modification and the confounding of effects by sex, smoking, and other factors.

The mechanism by which selenium protects against the toxicity of methylmercury is not known, but the fact that vitamin E and certain antioxidants also decrease methylmercury toxicity (Welsh & Soares, 1976; Welsh, 1979) has prompted the hypothesis that these compounds may diminish methylmercury toxicity by counteracting the damaging effects of the free radicals generated by its breakdown (Ganther, 1978).